Donor age and breed determine mesenchymal stromal cell characteristics
Our findings clearly show the impact of donor characteristics such as age and breed on MSC proliferation, immunophenotype, and differentiation potential, illustrating the importance of selecting the appropriate MSC donor for MSC-based treatments when allogeneic MSCs are considered.
Authors
- Lieven Thorrez (ORCID: https://orcid.org/0000-0002-5896-6823)
- Stefaan De Smet (ORCID: https://orcid.org/0000-0003-1422-805X)
- Emma Heyman
- Maria Olenic (ORCID: https://orcid.org/0000-0002-0766-3080)
- Catharina De Schauwer
- Bert Devriendt (ORCID: https://orcid.org/0000-0002-3222-8769)
- Elly De Vlieghere (ORCID: https://orcid.org/0000-0003-0618-2258)
Institutions
- Ghent University (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s13287-025-04236-2
- Citations
- 12
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 19.50
Funders
- Fonds Wetenschappelijk Onderzoek
- Universiteit Gent
- Vlaamse regering