ARv7 promotes the escape of prostate cancer cells from androgen deprivation therapy-induced senescence by mediating the SKP2/p27 axis
Our work reveals a novel role of ARv7 in regulating AIS and suggests that targeting the ARv7/SKP2/p27 axis could be a potential strategy to delay disease progression to the CRPC state during prolonged ADT.
Authors
- Jinsong Kang (ORCID: https://orcid.org/0000-0003-4875-1818)
- Wenjun Li (ORCID: https://orcid.org/0000-0001-5335-7386)
- Tian Yu (ORCID: https://orcid.org/0000-0001-9279-3076)
- Chen Shao
- Dian Zhuang (ORCID: https://orcid.org/0000-0002-0771-3869)
- Haoge Luo
Institutions
- Jilin University (CN)
- Jilin Medical University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12915-025-02172-4
- Citations
- 8
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 12.15