Effectiveness of placental blood perfusion monitoring of nitroglycerin and labetalol in treatment of women with pregnancy-induced hypertension

This was an original study and elucidated the value of placental blood perfusion monitoring based on quantitative three-dimensional (3D) power Doppler ultrasound in evaluating the efficacy of nitroglycerin and labetalol in treating pregnancy-induced hypertension (PIH). Eighty PIH patients admitted in The Second Affiliated Hospital from October 2021 to October 2023 were divided into mild PIH group (Group A) and severe PIH group (Group B). Another 50 healthy pregnant women without PIH were selected as the control group (CG). Groups A and B received a combination treatment of nitroglycerin and labetalol. The TNF-α levels in Group A and B were higher relative to those in CG. Relative to before treatment, Group A and B had higher vascularization index (VFI), flow index (FI), and placental vascularization index (VI), higher middle cerebral artery pulsatility index (PI) and Apgar scores and lower left uterine artery PI and right uterine artery PI after treatment. After treatment, there was statistical significance in placental VI, FI, and VFI under different efficacy grades. We conclude that the application of quantitative 3D power Doppler ultrasound technology can accurately monitor the therapeutic effect of nitroglycerin and labetalol in treatment of pregnant women with PIH.