Frequency and Determinants of Flare and Persistently Active Disease in a Large Multinational Prospective Lupus Cohort
Both flare and PAD are common disease activity patterns in SLE; both predict organ damage accrual but differ in disease features and predictive factors. Because 9.7% of patients experience PAD but not flare, flare measures alone do not adequately capture all patients in whom disease control is suboptimal.
Authors
- Sean O’Neill (ORCID: https://orcid.org/0000-0002-6739-832X)
- Chak Sing Lau (ORCID: https://orcid.org/0000-0001-6698-8355)
- Cherica Tee (ORCID: https://orcid.org/0000-0002-0766-0189)
- Masayoshi Harigai (ORCID: https://orcid.org/0000-0002-6418-2603)
- Mandana Nikpour (ORCID: https://orcid.org/0000-0002-6585-5611)
- Jun Kikuchi (ORCID: https://orcid.org/0000-0002-6809-394X)
- Yoshiya Tanaka (ORCID: https://orcid.org/0000-0002-0807-7139)
- Shereen Oon (ORCID: https://orcid.org/0000-0002-6822-5711)
- Sang‐Cheol Bae (ORCID: https://orcid.org/0000-0003-4658-1093)
- Eric Francis Morand (ORCID: https://orcid.org/0000-0002-9507-3338)
- Zhanguo Li (ORCID: https://orcid.org/0000-0002-2590-6242)
- Nicola Tugnet
- Alberta Hoi (ORCID: https://orcid.org/0000-0002-9416-7383)
- Lanlan Ji (ORCID: https://orcid.org/0000-0001-9620-8882)
- Madelynn Chan (ORCID: https://orcid.org/0000-0002-8102-7664)
- Naoaki Ohkubo (ORCID: https://orcid.org/0000-0003-2265-4104)
- Vera Golder (ORCID: https://orcid.org/0000-0001-5691-4344)
- Yasuhiro Katsumata (ORCID: https://orcid.org/0000-0003-1654-0119)
- Fiona Goldblatt (ORCID: https://orcid.org/0000-0001-7205-4807)
- Zhuoli Zhang (ORCID: https://orcid.org/0000-0001-7219-9141)
- Yanjie Hao (ORCID: https://orcid.org/0000-0001-8715-259X)
- Worawit Louthrenoo (ORCID: https://orcid.org/0000-0003-3105-6122)
- Jiacai Cho (ORCID: https://orcid.org/0000-0002-4477-3430)
- BMDB Basnayake
- Laniyati Hamijoyo (ORCID: https://orcid.org/0000-0002-1310-674X)
- Rangi Kandane‐Rathnayake (ORCID: https://orcid.org/0000-0001-5397-1482)
- Tsutomu Takeuchi (ORCID: https://orcid.org/0000-0003-1111-8218)
- Michael Tee (ORCID: https://orcid.org/0000-0003-0113-8290)
- Aisha Lateef (ORCID: https://orcid.org/0000-0002-0838-7495)
- Ning Li (ORCID: https://orcid.org/0000-0001-8013-5041)
- Yi‐Hsing Chen (ORCID: https://orcid.org/0000-0002-8135-9554)
- Dylan Hansen (ORCID: https://orcid.org/0000-0001-5777-7476)
- Sandra Navarra
- Leonid Zamora
- Sargunan Sockalingam
- Kristine Ng (ORCID: https://orcid.org/0009-0006-6225-2715)
- Shue Fen Luo
- Yeong-Jian Jan Wu
Institutions
- University of Santo Tomas Hospital (PH)
- The University of Melbourne (AU)
- Chinese University of Hong Kong (HK)
- University of Occupational and Environmental Health Japan (JP)
- Peking University (CN)
- Keio University (JP)
- Royal Prince Alfred Hospital (AU)
- Liverpool Hospital (AU)
- Tan Tock Seng Hospital (SG)
- Teaching Hospital Kandy (LK)
- Flinders Medical Centre (AU)
- University of Malaya (MY)
- Dr. Hasan Sadikin General Hospital (ID)
- St Vincent's Hospital Melbourne (AU)
- Taichung Veterans General Hospital (TW)
- Greenlane Clinical Centre (NZ)
- Taoyuan Chang Gung Memorial Hospital (TW)
- Waitemata District Health Board (NZ)
- Monash Health (AU)
- Peking University People's Hospital (CN)
- Peking University First Hospital (CN)
- Tokyo Women's Medical University (JP)
- Woodlands Health Campus (SG)
- National University Hospital (SG)
- Hanyang University (KR)
- Chiang Mai University (TH)
- Monash University (AU)
- University of the Philippines Manila (PH)
- Saitama Medical University (JP)
- University of Hong Kong (HK)
- Padjadjaran University (ID)
Publication Details
- Journal
- ACR Open Rheumatology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1002/acr2.70007
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Melbourne
- EMD Serono
- Eli Lilly Australia
- Janssen Research and Development