A robust optimization model for intensity‐modulated radiotherapy: Cheap‐Minimax

The c-minimax model successfully overcomes the limitations of the PTV approach and the over-conservativeness of the minimax model, demonstrating significant advantages in managing uncertainties in complex cases, such as breast cancer. By providing superior robustness compared to PTV and reducing OAR doses relative to minimax, the model offers a flexible and clinically feasible strategy to enhance treatment quality. The marked reduction in high-dose regions (hotspots) in superficial tissues and skin highlights its potential to lower toxicity risks and improve patient outcomes. These results provide quantitative evidence of the practical benefits of robustness-compromise-oriented approaches in IMRT.

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Publication Details

Journal
Medical Physics
Published
2025-02-26
DOI
https://doi.org/10.1002/mp.17709
Primary Topic
Advanced Radiotherapy Techniques
Type
article
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article

A robust optimization model for intensity‐modulated radiotherapy: Cheap‐Minimax

Gonzalo Cabal, Juan Carlos Rivera, Niklas Wahl, Andrés C. Sevilla et al.
Medical Physics
Advanced Radiotherapy Techniques
article

A robust optimization model for intensity‐modulated radiotherapy: Cheap‐Minimax

Gonzalo Cabal, Juan Carlos Rivera, Niklas Wahl, Andrés C. Sevilla, Maria Eugenia Puerta
article en

Abstract

The c-minimax model successfully overcomes the limitations of the PTV approach and the over-conservativeness of the minimax model, demonstrating significant advantages in managing uncertainties in complex cases, such as breast cancer. By providing superior robustness compared to PTV and reducing OAR doses relative to minimax, the model offers a flexible and clinically feasible strategy to enhance treatment quality. The marked reduction in high-dose regions (hotspots) in superficial tissues and skin highlights its potential to lower toxicity risks and improve patient outcomes. These results provide quantitative evidence of the practical benefits of robustness-compromise-oriented approaches in IMRT.

Medical PhysicsVol. 52(5)
German Cancer Research Center (DE), Heidelberg University (DE), Clínica Santa María (CO), Universidad EAFIT (CO)
Good health and well-being
Openalex Percentile: Top 95%
Advanced Radiotherapy Techniques
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