Cleaving <scp>PINK1</scp> or <scp>PGAM5</scp>? Involvement of <scp>PARL</scp> in Methamphetamine‐Induced Excessive Mitophagy and Neuronal Necroptosis
In summary, these findings collectively underscore the key roles of the PARL-PGAM5 axis in Meth-mediated neuronal necroptosis and that targeting this axis may provide promising therapeutic strategies for mitigating Meth-induced neurotoxicity.
Authors
- Rong Gao (ORCID: https://orcid.org/0000-0002-2594-1718)
- Yanlong Chen (ORCID: https://orcid.org/0000-0001-6771-5201)
- Jianping Xiong (ORCID: https://orcid.org/0000-0003-0398-6090)
- Weixiao Xu
- Jie Cheng (ORCID: https://orcid.org/0000-0001-9068-4271)
- Shunlong Meng (ORCID: https://orcid.org/0000-0002-8906-2894)
- Yifei Wang (ORCID: https://orcid.org/0000-0001-6025-8407)
- Jun Wang (ORCID: https://orcid.org/0000-0002-6120-6075)
- Di An (ORCID: https://orcid.org/0000-0001-6171-7791)
- Jianhua Xuan (ORCID: https://orcid.org/0000-0001-7256-1374)
- Peng Zhou (ORCID: https://orcid.org/0000-0001-8328-6320)
- Xufeng Chen (ORCID: https://orcid.org/0000-0003-3697-6446)
- Cuishan Zhang
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/cns.70293
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Natural Science Foundation of China