IA-2A positivity increases risk of progression within and across established stages of type 1 diabetes
IA-2A positivity is consistently associated with increased progression risk throughout the natural history of type 1 diabetes development. Individuals with single-autoantibody positivity for IA-2A have a greater risk of disease progression than those who meet stage 1 criteria but who are IA-2A<sup>-</sup>. Approaches to incorporate IA-2A<sup>+</sup> status into monitoring strategies for autoantibody-positive individuals should be considered.
Authors
- Richard A. Oram (ORCID: https://orcid.org/0000-0003-3581-8980)
- MARIA JOSE REDONDO (ORCID: https://orcid.org/0000-0001-5871-4645)
- Emily K. Sims (ORCID: https://orcid.org/0000-0002-4393-954X)
- Heba M. Ismail (ORCID: https://orcid.org/0000-0003-0102-0030)
- Linda Anne DiMeglio (ORCID: https://orcid.org/0000-0002-8033-6078)
- Emanuele Bosi (ORCID: https://orcid.org/0000-0002-4769-8667)
- Lauric Ferrat (ORCID: https://orcid.org/0000-0002-3166-9685)
- Jay M. Sosenko (ORCID: https://orcid.org/0000-0002-7204-8367)
- David D Cuthbertson (ORCID: https://orcid.org/0000-0002-3785-9834)
- Carmella Evans‐Molina (ORCID: https://orcid.org/0000-0001-7764-8663)
- Brandon M. Nathan (ORCID: https://orcid.org/0000-0001-6405-3994)
- Laura M. Jacobsen (ORCID: https://orcid.org/0000-0002-5144-7836)
Institutions
- University of Geneva (CH)
- University of Minnesota (US)
- University of Miami (US)
- Vita-Salute San Raffaele University (IT)
- Baylor College of Medicine (US)
- University of Exeter (GB)
- University of South Florida (US)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- University of Florida (US)
- Richard L. Roudebush VA Medical Center (US)
- Texas Children's Hospital (US)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1007/s00125-025-06382-x
- Citations
- 9
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 16.36
Funders
- Doris Duke Charitable Foundation
- John Templeton Foundation
- Ralph W. and Grace M. Showalter Research Trust Fund
- Diabetes UK
- National Institute of Diabetes and Digestive and Kidney Diseases