Evaluation of the Regulatory Effect of the Pan-PPAR Agonist Chiglitazar on the Dawn Phenomenon
Chiglitazar effectively reduces DP intensity and improves glycemic control, independent of its effects on lipid metabolism. These findings suggest a potential link between chiglitazar's mechanism and circadian rhythm regulation, possibly through the modulation of REV-ERB nuclear receptors. Further research is needed to confirm this hypothesis and evaluate the long-term clinical benefits of chiglitazar in diabetes management.
Authors
- Chuanfeng Liu (ORCID: https://orcid.org/0000-0002-6549-2013)
- Yongzhuo Yu (ORCID: https://orcid.org/0009-0008-5412-5059)
- Wenxuan Li (ORCID: https://orcid.org/0000-0001-8641-3954)
- Bingzi Dong (ORCID: https://orcid.org/0000-0003-2446-0725)
- Yangang Wang (ORCID: https://orcid.org/0000-0001-6597-420X)
- Lili Xu (ORCID: https://orcid.org/0000-0001-8759-1568)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Diabetes Therapy
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1007/s13300-025-01708-9
- Citations
- 4
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.66