Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice
This study elucidates that diet-induced obesity altered the lipid and miRNA profiles of AT-Exos, which involved in modulating adipocyte inflammation and metabolic balance. The SIRPα-CD47 axis emerges as a potential therapeutic target for obesity and its associated complications.
Authors
- Yexiong Tan
- Liwei Dong (ORCID: https://orcid.org/0000-0003-2116-1674)
- Tianyi Jiang (ORCID: https://orcid.org/0000-0002-0515-4434)
- Yun‐Kai Lin (ORCID: https://orcid.org/0009-0006-3343-0017)
- Taiyu Shang
- Hongyang Wang (ORCID: https://orcid.org/0000-0002-4709-3334)
- Yunhan Ma
- Yufei Pan (ORCID: https://orcid.org/0000-0002-7658-9064)
- Min Xu (ORCID: https://orcid.org/0000-0001-9455-9494)
- Hailan Feng (ORCID: https://orcid.org/0000-0002-7640-5990)
- Yibin Chen (ORCID: https://orcid.org/0009-0004-0423-5218)
Institutions
- Second Military Medical University (CN)
- Renji Hospital (CN)
- Shanghai Cancer Institute (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
- State Key Laboratory of Oncogene and Related Genes (CN)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-02-28
- DOI
- https://doi.org/10.1186/s12929-025-01124-y
- Citations
- 13
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China