PRMT5 attenuates regorafenib-induced DNA damage in hepatocellular carcinoma cells through symmetric dimethylation of RPL14
PRMT5-mediated symmetric dimethylation of RPL14 stabilizes the protein, promoting DNA damage repair and contributing to regorafenib resistance in HCC. RPL14 plays a key role in PRMT5-driven enhancement of DNA damage repair and reduced drug sensitivity, identifying RPL14 as a potential therapeutic target to overcome regorafenib resistance in HCC.
Authors
- Xinyu Jiang (ORCID: https://orcid.org/0000-0002-2095-6208)
- Huisi He
- Xiaoqing Jiang
- Lingchang Jiang (ORCID: https://orcid.org/0000-0003-2054-1851)
- Zhecai Fan
- Xiaojuan Sun (ORCID: https://orcid.org/0000-0003-3668-7628)
- Hailing Huang
- Wendi Bi
- Qiuyun Yi
- Wen Wen (ORCID: https://orcid.org/0000-0003-2958-0451)
Institutions
- Second Military Medical University (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/jgo-24-737
- Citations
- 2
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.61