Liver microsomal protein content and activity in patients with hepatocellular carcinoma and cirrhosis: implications for the in vivo prediction of individual hepatic clearance
In patients with HCCC, MPPGL content was significantly reduced, and a variable change in the activity of 10 CYP was observed in microsomes. When taking individual MPPGL into account, CL<sub>L</sub> is better suited than CL<sub>M</sub> to represent the <i>in vitro</i> metabolism of CYPs, with the strongest correlation being observed between CL<sub>L</sub> and <i>in vivo</i> CL<sub>H</sub>. This finding holds potential value for guiding clinical management of drugs in patients with HCCC.
Authors
- Jie Gao (ORCID: https://orcid.org/0000-0002-4648-7956)
- Sai-Fei Li
- Hai–Ling Qiao (ORCID: https://orcid.org/0000-0002-8533-344X)
- Xin Tian (ORCID: https://orcid.org/0000-0003-0392-6362)
- Yunfei Zhang (ORCID: https://orcid.org/0000-0001-7930-5189)
- Yan Fang (ORCID: https://orcid.org/0000-0002-6267-804X)
- Na Gao (ORCID: https://orcid.org/0000-0001-9319-3195)
- Jun Zhou (ORCID: https://orcid.org/0000-0003-0171-9263)
- Mingzhu Cui
- Qiang Wen (ORCID: https://orcid.org/0000-0002-3437-2457)
- Lin-Jing Jia
Institutions
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
- Henan Cancer Hospital (CN)
Publication Details
- Journal
- Journal of Gastrointestinal Oncology
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/jgo-2024-963
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35