Often neglected steps in transforming drug solubility from single measurement in pure water to physiologically-appropriate solubility-pH
This commentary re-emphasizes that measured <i>S</i> <sub>w</sub> is not generally the same as <i>S</i> <sub>0</sub>. It is stressed that transforming measured drug solubility in pure water to an ionic strength level that is physiologically appropriate would better match the conditions found in biological media, potentially improving applications of solubility in pharmaceutical research and development.
Authors
- Alex Avdeef (ORCID: https://orcid.org/0000-0002-3139-5442)
Institutions
- Adaptive Design Association (US)
- Agence pour le développement de l'emploi (LU)
Publication Details
- Journal
- ADMET & DMPK
- Published
- 2025-02-26
- DOI
- https://doi.org/10.5599/admet.2626
- Citations
- 4
- Primary Topic
- Crystallization and Solubility Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.07