CLINICAL EFFECTIVENESS OF PRP THERAPY IN THE COMPREHENSIVE TREATMENT OF TROPНICAL ULCERATIONS OF THE LOWER EXTREMITIES

Treatment of trophic ulcers of the lower extremities of various origins remains one of the current scientific and practical problems of surgery today. In recent years, the use of autologous platelet-rich plasma as a factor for stimulating soft tissue regeneration has gained considerable popularity. The aim of this study was to evaluate the effectiveness of PRP therapy in the complex treatment of trophic ulcers of the lower extremities. When analyzing the obtained data, a positive effect of the PRP therapy method on the early appearance of granulation tissue was revealed, and its smaller effect on the epithelialization process compared to the comparison group. In each specific case, the presence of concomitant vascular pathology and metabolic changes was taken into account, but the trend of the healing process indicated a clear positive effect of the PRP therapy method on wound cleansing and the appearance of granulations earlier in patients in the main group than in the comparison group. The dynamics had a linear, decreasing nature, which was clinically characterized by a decrease in inflammatory changes in the wound, already after the first 3 days of treatment using the specified method. In the comparative analysis, it should be noted that the largest changes, the difference in the indicators of patients in the main group occurred in the indicators "Swelling" and "Exudation", a somewhat smaller dynamics of changes was observed in the indicator "Hyperemia". Conclusion. The use of the treatment method using autologous platelet-rich plasma allowed to reduce the patient's hospital stay by more than 10 %, accelerated the cleansing of the wound from necrotic tissues and the transition of the wound process to the second phase, and stimulated the early appearance of granulations several days earlier than in patients in the comparison group.