Unravelling the complexity of EGFR-mutated lung adenocarcinoma: a unique case report with histological transformations and co-alteration acquisition
To our knowledge, this case is the first reported incidence of transformation into large cell carcinoma coupled with a second acquisition of alterations in ALK. These findings underscore the necessity of monitoring patients with oncogenic addiction through both liquid biopsy for on-target mechanism detection and tissue sampling to detect histological transformations. These mechanisms can occasionally be combined, thereby providing comprehensive panels at each stage of tumour progression.
Authors
- A. Durlach (ORCID: https://orcid.org/0000-0002-3330-3505)
- Julien Ancel (ORCID: https://orcid.org/0000-0003-3128-9348)
- Véronique Dalstein (ORCID: https://orcid.org/0000-0003-1311-7147)
- Maxime Dewolf (ORCID: https://orcid.org/0000-0002-7856-8742)
- Chistine Clavel
- Gaëtan Deslée (ORCID: https://orcid.org/0000-0002-4919-5916)
- Jean Baptiste Oudart
- Anissa Boutahir
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Reims Champagne-Ardenne (FR)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/tlcr-24-707
- Citations
- 2
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 3.04