Partial response to lorlatinib in thoracic inflammatory myofibroblastic tumor harboring complex and rare ALK fusions: a case report
This is the inaugural case of a third-generation ALK-TKI achieving therapeutic success in advanced IMT with complex ALK rearrangements, including rare and previously uncharacterized fusion subtypes. Although the biological functions of these two rare ALK fusions still need to be confirmed, this case underscores the dependency of ALK-rearranged IMT on ALK-mediated signaling, suggesting that third-generation ALK-TKIs may offer an optimal targeted therapeutic strategy for ALK-dependent mesenchymal tumor subtypes.
Authors
- Chong‐Rui Xu (ORCID: https://orcid.org/0000-0002-3474-2809)
- Yinglong Peng (ORCID: https://orcid.org/0000-0002-7162-4422)
- Lu Sun (ORCID: https://orcid.org/0000-0003-1833-2364)
- Zhi Hong Chen (ORCID: https://orcid.org/0000-0001-6048-5917)
- Shichao Lv (ORCID: https://orcid.org/0000-0002-4073-9083)
- Chang Lu (ORCID: https://orcid.org/0009-0008-6107-6099)
- Mei-Mei Zheng (ORCID: https://orcid.org/0000-0002-3493-7139)
- Qing Zhou (ORCID: https://orcid.org/0000-0002-0478-176X)
- Yang Zheng (ORCID: https://orcid.org/0000-0002-6793-3206)
- Li‐Xu Yan (ORCID: https://orcid.org/0000-0002-5584-4265)
- Yu Deng (ORCID: https://orcid.org/0000-0001-5391-2474)
- Xiaorong Yang (ORCID: https://orcid.org/0009-0004-1275-304X)
- Li-Bo Tang (ORCID: https://orcid.org/0000-0002-4870-4408)
- Jia-Ting Li
Institutions
- Shantou University (CN)
- Soochow University (CN)
- Shantou University Medical College (CN)
- Guangdong Academy of Medical Sciences (CN)
- Guangdong Provincial People's Hospital (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/tlcr-24-963
- Citations
- 3
- Primary Topic
- IgG4-Related and Inflammatory Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.00