Whole-section digital analysis of immune profiles in surgically resected small cell lung carcinoma and their associations with molecular subtypes
This study highlights the heterogeneity of the TIME across molecular subtypes of SCLC. The SCLC-P subtype and MHC I expression may serve as predictive biomarkers for immunotherapy response, while peri-TLS density and stromal PD-L1 expression might serve as prognostic indicators in resected SCLC.
Authors
- Kaiwen Chi (ORCID: https://orcid.org/0000-0001-6824-2477)
- Yanli Zhu (ORCID: https://orcid.org/0000-0003-2581-2067)
- Jianghua Wu (ORCID: https://orcid.org/0000-0001-7351-8933)
- Minglei Zhuo (ORCID: https://orcid.org/0000-0003-2489-7791)
- Xinting Diao
- Haiyue Wang (ORCID: https://orcid.org/0000-0002-0350-1308)
- Dongmei Lin
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/tlcr-24-924
- Citations
- 4
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.18