Rapid detection of non-small cell lung cancer driver mutations using droplet digital polymerase chain reaction analysis of bronchial washings: a prospective multicenter study
ddPCR analysis of BWs demonstrates high accuracy and rapid TAT for detecting common driver mutations in NSCLC. This approach represents a promising alternative to tissue biopsy for molecular profiling, potentially expediting treatment decisions. While serum ddPCR showed limited utility, it may complement tissue genotyping in specific clinical scenarios.
Authors
- Ayami Kaneko
- Yukihito Kajita
- Satoshi Nagaoka (ORCID: https://orcid.org/0009-0002-9786-8668)
- Nobuaki Kobayashi (ORCID: https://orcid.org/0000-0002-7064-320X)
- Shuhei Teranishi (ORCID: https://orcid.org/0000-0003-2365-144X)
- Ryo Nagasawa (ORCID: https://orcid.org/0000-0003-0078-2789)
- Kenichi Seki
- Kohei Somekawa
- Makoto Kudo (ORCID: https://orcid.org/0000-0002-1837-0267)
- Kota Murohashi (ORCID: https://orcid.org/0000-0002-2637-8218)
- Takeshi Kaneko (ORCID: https://orcid.org/0000-0001-9292-307X)
- Keisuke Watanabe (ORCID: https://orcid.org/0000-0001-9623-1492)
- Nobuyuki Horita (ORCID: https://orcid.org/0000-0002-8200-0340)
- Yu Hara (ORCID: https://orcid.org/0000-0002-2574-2516)
- Ken Tashiro
- Ami Izawa (ORCID: https://orcid.org/0009-0006-7549-2734)
- Yukiko Otsu
- Momo Hirata
- Hiroaki Fuji
- Suguru Muraoka
- Sousuke Kubo
Institutions
- Yokohama City University Medical Center (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Translational Lung Cancer Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.21037/tlcr-24-772
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00