Pathomorphological Aspects of the Regenerative Process of Wounds Caused by the Use of Collagen Wound Coatings in Patients with Diabetic Foot Syndrome

Purpose: to evaluate the morphological features of the course of reparative processes in patients with diabetic foot syndrome (DFS) due to the use of collagen wound coatings. Material and methods. the paper presents a comparative retrospective analysis of the histological material of wound tissues of 112 DFS patients. Morphological examination of the material was carried out using a microscope “Micros MC 50”, a lens “WF EWF 10x/18”. The studied material is divided into two groups: the main one is 62 micro-preparations of the wound tissue of DFS patients, collagen wound coatings (“Green Oak”, RF) were used in the complex treatment of wound defects; The control group consisted of 60 micro–preparations of wound tissues of DFS patients, local treatment of wound defects consisted of daily dressings with antiseptics and ointments. Results and discussion. fnalysis of the obtained results showed that the use of collagen wound coatings affects each phase of the reparative process of chronic wounds of DFS patients, contributes to a faster transition from the alternativeexudative stage of inflammatory reaction in proliferative and epithelial phase; collagen absorbs wound exudate, performing a drainage function, contributing to acceleration of wound cleansing processes, reduces inflammatory reaction, normalizes the functioning of microcirculatory vessels, stabilizing blood supply in the area of wound defect and reducing hypoxia, leads to the activation of reparative processes; the use of collagen wound coatings activates the process of leukocyte migration, significantly increases the number of macrophages, promoting increased expression of proinflammatory cytokines, speeds up the process of angiogenesis, migration and proliferation of fibroblasts – granulation tissue in the wounds undergoes a maturation process much faster than the group of patients, treated with daily bandages with antiseptics and ointments. Conclusion. the use of collagen wound coatings in the complex treatment of patients with purulent necrotic DFS forms can significantly accelerate the course of each phase of the reparative process in wound defects due to the influence of this technique granulation tissue is able to pass the process of maturation in a shorter period of time, allowing to reduce the time of preparation for plastic closure from 20-22 to 12-16 days.