Evaluation and assessment of the effects of various antibiotics and phages on staphylococcus aureus bacteria

Pyogenic cocci are among the most significant pathogens responsible for both hospital-acquired and community-acquired infections, leading to considerable morbidity and mortality worldwide. Over the past few decades, since the advent of antibiotics, the emergence and spread of methicillin-resistant Staphylococcus aureus (MRSA) have become a serious healthcare challenge. In this study, patients with Staphylococcal infections were observed in two major hospitals located in Tashkent city. Monitoring revealed a sharp increase in infection rates over the last three years, particularly in 2021-2023, with 3,695 infections recorded at the Tashkent Medical Academy and 14,632 cases at the Republican Scientific Center for Emergency Medical Care during the same period. Considering this situation, the effects of various antibiotics and bacteriophages as alternative treatments for Staphylococcus infections were studied. Results showed significant effectiveness with Cefoperazone + Sulbactam (2.8 cm), Fosfosin (2.7 cm), Cefepime (2.7 cm), Amikacin (2.6 cm), Levofloxacin (2.7 cm), Doxycycline (2.6 cm each), and Levomycetin (2.7 cm). The bacteriophage demonstrated an efficacy of 1.5 cm within 12 hours.