ENTEROVIRUSES AND THEIR SENSITIVITY TO FLAVONOIDS

The review highlights the current state of research on enteroviruses, in particular polioviruses, ECHO viruses, Coxsackie, and enterovirus type 71, which cause a significant number of human infectious diseases. The main aspects of their replication, pathogenesis, and molecular biological properties are discussed. Particular attention is paid to the prospects for the use of flavonoids as antiviral agents. The mechanisms of their action are analyzed, including the inhibition of proteases and blocking the interaction of viral components with cellular targets. The cytotoxicity and antiviral efficacy of a number of flavonoid compounds in model systems are considered. The review emphasizes the importance of searching for new natural substances and synthetic derivatives for the development of therapeutic agents against enterovirus infections, given the limitations of existing treatment options and the peculiarities of the mutagenicity of these viruses.