Comparing Alzheimer's genes in African, European, and Amerindian induced pluripotent stem cell–derived microglia
First comparison of the genomics of AI, AF, and EU microglia. Report differences in expression and accessibility of AD genes between ancestries. Ancestral expression differences are greater than differences in accessibility. Good transcriptome correlation was seen between brain and iPSC-derived microglia. Differentially expressed AD genes were in known AD pathways.
Authors
- Mario Cornejo‐Olivas (ORCID: https://orcid.org/0000-0001-6313-5680)
- Juan I. Young
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Maryenela Illanes‐Manrique (ORCID: https://orcid.org/0000-0002-3098-0981)
- Sofia Moura (ORCID: https://orcid.org/0000-0002-9000-2290)
- Farid Rajabli (ORCID: https://orcid.org/0000-0001-5229-7254)
- Patrice L. Whitehead
- Goldie S. Byrd (ORCID: https://orcid.org/0000-0003-1057-0261)
- Jeffery M. Vance (ORCID: https://orcid.org/0000-0003-3815-8199)
- Kara L. Hamilton‐Nelson (ORCID: https://orcid.org/0000-0003-3748-7193)
- Karen Nuytemans (ORCID: https://orcid.org/0000-0003-2670-4914)
- Aura M. Ramírez (ORCID: https://orcid.org/0009-0007-8892-5743)
- Brooke A. DeRosa (ORCID: https://orcid.org/0000-0002-7878-9799)
- Briseida E. Feliciano‐Astacio (ORCID: https://orcid.org/0000-0003-4747-8928)
- Takiyah D. Starks (ORCID: https://orcid.org/0000-0001-7267-3480)
- Luciana Bertholim Nasciben (ORCID: https://orcid.org/0009-0002-1518-1409)
- Derek J. Van Booven (ORCID: https://orcid.org/0000-0002-5136-7318)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Sergio Tejada
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Lauren Coombs
- Liyong Wang (ORCID: https://orcid.org/0000-0001-8299-2602)
- Margaret A. Pericak‐Vance
- Larry D. Adams
- Joe Rivero
Institutions
- University of Miami (US)
- Central University of the Caribbean (PR)
- Universidad Científica del Sur (PE)
- Dr. John T. Macdonald Foundation (US)
- Instituto Nacional de Ciencias Neurológicas
- Wake Forest University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.70031
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 4.21
Funders
- University of Miami
- Leonard M. Miller School of Medicine
- National Institute on Aging