Comparing Alzheimer's genes in African, European, and Amerindian induced pluripotent stem cell–derived microglia

First comparison of the genomics of AI, AF, and EU microglia. Report differences in expression and accessibility of AD genes between ancestries. Ancestral expression differences are greater than differences in accessibility. Good transcriptome correlation was seen between brain and iPSC-derived microglia. Differentially expressed AD genes were in known AD pathways.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-02-01
DOI
https://doi.org/10.1002/alz.70031
Citations
5
Primary Topic
Neuroinflammation and Neurodegeneration Mechanisms
Type
article
Field-Weighted Citation Impact
4.21

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article

Comparing Alzheimer's genes in African, European, and Amerindian induced pluripotent stem cell–derived microglia

Mario Cornejo‐Olivas, Juan I. Young, Derek M. Dykxhoorn, Maryenela Illanes‐Manrique et al.
5 citations
Alzheimer s & Dementia
Neuroinflammation and Neurodegeneration Mechanisms
4.21
article

Comparing Alzheimer's genes in African, European, and Amerindian induced pluripotent stem cell–derived microglia

Mario Cornejo‐Olivas, Juan I. Young, Derek M. Dykxhoorn, Maryenela Illanes‐Manrique, Sofia Moura, Farid Rajabli, Patrice L. Whitehead, Goldie S. Byrd, Jeffery M. Vance, Kara L. Hamilton‐Nelson, Karen Nuytemans, Aura M. Ramírez, Brooke A. DeRosa, Briseida E. Feliciano‐Astacio, Takiyah D. Starks, Luciana Bertholim Nasciben, Derek J. Van Booven, Pedro Mena, Sergio Tejada, Anthony J. Griswold, Lauren Coombs, Liyong Wang, Margaret A. Pericak‐Vance, Larry D. Adams, Joe Rivero
article en
5 citations

Abstract

First comparison of the genomics of AI, AF, and EU microglia. Report differences in expression and accessibility of AD genes between ancestries. Ancestral expression differences are greater than differences in accessibility. Good transcriptome correlation was seen between brain and iPSC-derived microglia. Differentially expressed AD genes were in known AD pathways.

Alzheimer s & DementiaVol. 21(2)
University of Miami (US), Central University of the Caribbean (PR), Universidad Científica del Sur (PE), Dr. John T. Macdonald Foundation (US), Instituto Nacional de Ciencias Neurológicas, Wake Forest University (US)
University of Miami, Leonard M. Miller School of Medicine, National Institute on Aging
Openalex Percentile: Top 6%
Neuroinflammation and Neurodegeneration Mechanisms
4.21
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