Plasma p‐tau217 identifies cognitively normal older adults who will develop cognitive impairment in a 10‐year window
Elevated plasma p-tau217 levels in CU individuals indicate future clinical progression. Adding plasma Aβ<sub>42/40</sub> status to p-tau markers did not improve the prediction to MCI. All individuals with abnormal tau PET measured in a temporal meta-ROI progressed to MCI.
Authors
- Christine Déry
- Judes Poirier
- Maiya R. Geddes (ORCID: https://orcid.org/0009-0000-2371-934X)
- Cherie Strikwerda‐Brown (ORCID: https://orcid.org/0000-0002-8384-2582)
- Frédéric St‐Onge (ORCID: https://orcid.org/0000-0002-5609-5729)
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Jean‐Paul Soucy (ORCID: https://orcid.org/0000-0001-6979-1259)
- John C.S. Breitner (ORCID: https://orcid.org/0000-0003-4229-4687)
- Valentin Ourry (ORCID: https://orcid.org/0000-0002-8535-9009)
- Yara Yakoub (ORCID: https://orcid.org/0000-0002-4769-7162)
- Maxime Montembeault (ORCID: https://orcid.org/0000-0002-9369-0498)
- Michael Schöll (ORCID: https://orcid.org/0000-0001-7800-1781)
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Sylvia Villeneuve (ORCID: https://orcid.org/0000-0003-2338-0467)
- Pedro Rosa‐Neto (ORCID: https://orcid.org/0000-0001-9116-1376)
- Nicholas J. Ashton
- Simon Ducharme (ORCID: https://orcid.org/0000-0002-7309-1113)
Institutions
- Alzheimer's Association (US)
- Montreal Neurological Institute and Hospital (CA)
- McGovern Institute for Brain Research (US)
- The University of Western Australia (AU)
- King's College London (GB)
- Douglas Mental Health University Institute (CA)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Institute for Neurodegenerative Disorders (US)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Banner Alzheimer’s Institute
- University College London (GB)
- McGill University (CA)
- Massachusetts Institute of Technology (US)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14537
- Citations
- 29
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 42.67
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Fondation Brain Canada
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- Fondation Jean-Louis Lévesque
- European Commission
- Hjärnfonden
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Alzheimerfonden
- UK Dementia Research Institute
- HORIZON EUROPE Framework Programme
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- HORIZON EUROPE Reforming and enhancing the European Research and Innovation system