Serum levels of hepatitis B core antibodies and hepatitis B core-related antigen at the time of nucleos(t)ide analog cessation and risk of severe flares in patients with chronic hepatitis B.
In this prospective study of patients who stopped NA, anti-HBc levels ≥300 IU/mL were associated with a low risk of developing virologic relapse and severe biochemical flares. Future research should confirm a potential protective effect of high anti-HBc IgG levels.
Authors
- Marc Bourlière (ORCID: https://orcid.org/0000-0001-8976-9200)
- Thierry Verbinnen (ORCID: https://orcid.org/0000-0001-8627-400X)
- Sandra De Meyer (ORCID: https://orcid.org/0000-0001-5524-7324)
- Oliver Lenz
- John Jezorwski
- Thomas Vanwolleghem (ORCID: https://orcid.org/0000-0002-0572-8741)
- Michael Biermer (ORCID: https://orcid.org/0000-0001-6993-8206)
- Ewa Janczewska (ORCID: https://orcid.org/0000-0002-5406-4603)
- Adam Bakala
- Kosh Agarwal (ORCID: https://orcid.org/0000-0002-4754-828X)
- Florian van Bömmel (ORCID: https://orcid.org/0000-0003-2679-0672)
- Thomas N. Kakuda (ORCID: https://orcid.org/0000-0001-6857-2572)
- Gloria Kim (ORCID: https://orcid.org/0000-0002-9082-0082)
- Kathleen Donohue (ORCID: https://orcid.org/0000-0001-7278-7592)
- Maria Buti
- Pietro Lampertico (ORCID: https://orcid.org/0000-0002-1026-7476)
Institutions
- Medical University of Silesia (PL)
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Maggiore (IT)
- IQVIA (United States) (US)
- Hôpital Saint Joseph (FR)
- King's College Hospital (GB)
- Leipzig University (DE)
- Cytel (United States) (US)
Publication Details
- Journal
- PubMed
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1097/hc9.0000000000000656
- Citations
- 2
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.71