Plasma proteomics for cognitive decline and dementia—A Southeast Asian cohort study
A total of 1441 plasma proteins were profiled in a Singaporean memory clinic cohort. We report prognostic plasma protein signatures for cognitive decline and dementia. External validation was performed in the cerebrospinal fluid proteome of a Caucasian cohort. A concordant proteomic signature was identified across both biofluids and cohorts. Further studies are needed to explore the therapeutic implications of these proteins for dementia.
Authors
- Narayanaswamy Venketasubramanian (ORCID: https://orcid.org/0000-0003-3593-6362)
- Siew Pang Chan (ORCID: https://orcid.org/0000-0001-6239-6483)
- Lee Lee Wong (ORCID: https://orcid.org/0000-0002-5396-4116)
- James D. Doecke (ORCID: https://orcid.org/0000-0003-2863-0293)
- Christopher Chen (ORCID: https://orcid.org/0000-0002-1047-9225)
- Mark Richards (ORCID: https://orcid.org/0000-0002-2023-8177)
- Eugene S.J. Tan (ORCID: https://orcid.org/0000-0001-7273-6883)
- Colin Louis Masters (ORCID: https://orcid.org/0000-0003-3072-7940)
- Oi Wah Liew (ORCID: https://orcid.org/0000-0001-5729-2700)
- Joyce Ruifen Chong (ORCID: https://orcid.org/0000-0002-2869-0096)
- Saima Hilal (ORCID: https://orcid.org/0000-0001-5434-5635)
- Ming Ann Sim (ORCID: https://orcid.org/0000-0002-5699-3553)
- Hyungwon Choi (ORCID: https://orcid.org/0000-0002-6687-3088)
- Mitchell K.P. Lai (ORCID: https://orcid.org/0000-0001-7685-1424)
- Yuan Cai (ORCID: https://orcid.org/0000-0002-7551-2866)
- Boon Yeow Tan
Institutions
- Commonwealth Scientific and Industrial Research Organisation (AU)
- The University of Melbourne (AU)
- National University of Singapore (SG)
- Chinese University of Hong Kong (HK)
- Florey Institute of Neuroscience and Mental Health (AU)
- Raffles Institution (SG)
- National University Heart Centre Singapore (SG)
- Australian e-Health Research Centre (AU)
- National University Health System (SG)
- St Luke's Hospital (SG)
- University of Otago (NZ)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14577
- Citations
- 13
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 15.14
Funders
- National University of Singapore
- National University Health System
- Medical Research Council
- National Medical Research Council