Posterior cingulate cortex microRNA dysregulation differentiates cognitive resilience, mild cognitive impairment, and Alzheimer's disease
MicroRNA (MiRNA) dysregulation is a well-established feature of Alzheimer's disease (AD). Novel miRNAs also distinguish subjects with mild cognitive impairment and putative resilience. MiRNAs correlate with cognitive performance and neuropathological burden. Select miRNAs are associated with AD risk with age as a significant covariate. MiRNA pathways include insulin, prolactin, kinases, and neurite plasticity.
Authors
- Bryan Maloney (ORCID: https://orcid.org/0000-0003-2364-9649)
- Michael Malek‐Ahmadi (ORCID: https://orcid.org/0000-0001-9901-3650)
- John S. Beck (ORCID: https://orcid.org/0000-0001-7799-3416)
- Stephen D. Ginsberg (ORCID: https://orcid.org/0000-0002-1797-4288)
- Scott Counts (ORCID: https://orcid.org/0000-0003-2851-9763)
- Elliott Jay Mufson (ORCID: https://orcid.org/0000-0003-4438-7334)
- Debomoy K. Lahiri (ORCID: https://orcid.org/0000-0002-1664-5933)
Institutions
- Grand Rapids Community College (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Alzheimer's Association (US)
- Barrow Neurological Institute (US)
- St. Joseph's Hospital and Medical Center (US)
- University of Arizona (US)
- Banner Alzheimer’s Institute
- Indiana University – Purdue University Indianapolis (US)
- New York University (US)
- Michigan State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.70019
- Citations
- 5
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Institutes of Health
- National Institute on Aging