Irisin‐mediated muscle‐renal crosstalk as a protective mechanism against contrast‐induced acute kidney injury via cGAS‐STING signalling inhibition
Irisin mediated muscle-kidney crosstalk mitigated tubular injury and inflammation. Irisin inhibited the cGAS-STING signalling activation via integrin αV/β5 in tubular epithelial cells. Irisin was a predictive biomarker and a promising candidate for CI-AKI.
Authors
- Ting Luo (ORCID: https://orcid.org/0000-0002-9670-4031)
- Suhua Li (ORCID: https://orcid.org/0000-0002-8254-3855)
- Weiyan Lai (ORCID: https://orcid.org/0000-0002-6859-5392)
- Qiang Huang (ORCID: https://orcid.org/0000-0002-2052-1140)
- Juan Sun (ORCID: https://orcid.org/0000-0001-6352-0589)
- Hui Peng
- Yanlin Wang (ORCID: https://orcid.org/0000-0002-6908-1529)
- Yuxiang Sun (ORCID: https://orcid.org/0000-0002-7001-8383)
- Long Peng (ORCID: https://orcid.org/0000-0002-2716-4537)
- Zhaoyong Hu
Institutions
- University of Connecticut (US)
- Sun Yat-sen University (CN)
- Baylor College of Medicine (US)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1002/ctm2.70235
- Citations
- 10
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 8.06
Funders
- National Natural Science Foundation of China