[Analysis of hub genes, pathways and immune checkpoints of CD8+ T cells in metastatic lymph nodes of head and neck squamous cell carcinoma in C3H/He mice].
Tumor-related signaling pathway of CD8+ T cells in mouse metastatic lymph nodes is significantly activated. The PD-1 expression level of CD8+ T in metastatic lymph nodes of mice and patients with HNSCC is markedly increased. Immunotherapy targeting CD8+ T cells may become a new strategy for the prevention and cure for lymph node metastasis of HNSCC.
Authors
- Nannan Han (ORCID: https://orcid.org/0000-0003-3592-9840)
- H.Q.X. Li
- Min Ruan (ORCID: https://orcid.org/0000-0001-7253-0324)
- Di Zhou (ORCID: https://orcid.org/0000-0002-2605-1274)
- Ming Yan (ORCID: https://orcid.org/0009-0003-2836-2548)
Institutions
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-01
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article