Independent associations of high‐density lipoprotein cholesterol and triglyceride levels with Alzheimer's disease and related dementias
Strong correlations between lipid levels are important considerations when investigating lipids as late-life risk factors for Alzheimer's disease and related dementias (ADRD). Low levels of high-density lipoprotein cholesterol (HDL-C) and triglycerides (TGs) were independently associated with an increased risk of ADRD. We found no evidence for an association between high HDL-C and increased ADRD risk after adjustment for TGs. High levels of TGs were consistently associated with a decreased risk of ADRD. There may be interaction between TG and HDL-C levels, where both low HDL-C and TG levels increase the risk of ADRD compared to average levels of both.
Authors
- M. Maria Glymour (ORCID: https://orcid.org/0000-0001-9644-3081)
- Akinyemi Oni‐Orisan (ORCID: https://orcid.org/0000-0002-5897-5543)
- Travis J. Meyers (ORCID: https://orcid.org/0000-0001-9186-9745)
- Scott C. Zimmerman (ORCID: https://orcid.org/0000-0002-4431-6520)
- Catherine Schaefer (ORCID: https://orcid.org/0000-0003-2644-055X)
- Minhyuk Choi (ORCID: https://orcid.org/0009-0000-6658-5054)
- Ronald M. Krauss (ORCID: https://orcid.org/0000-0002-1238-3489)
- Erin L. Ferguson (ORCID: https://orcid.org/0000-0003-3136-0001)
- Neil Risch (ORCID: https://orcid.org/0000-0002-4126-2061)
- Chen Jiang (ORCID: https://orcid.org/0000-0002-0336-4518)
- Paola Gilsanz (ORCID: https://orcid.org/0000-0002-7635-381X)
- Rachel A. Whitmer (ORCID: https://orcid.org/0009-0006-9511-6138)
- Jingxuan Wang (ORCID: https://orcid.org/0000-0003-0380-6352)
- Thomas J. Hoffmann
Institutions
- Boston University (US)
- Kaiser Permanente (US)
- University of California, San Francisco (US)
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/alz.14575
- Citations
- 7
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 14.04
Funders
- Ellison Medical Foundation
- Wayne and Gladys Valley Foundation
- Kaiser Permanente
- National Institutes of Health
- National Institute on Aging