Data-driven projections of candidate enhancer-activating SNPs in immune regulation
Our findings highlight the value of combining genomic, epigenomic, and cross-species conservation data to effectively narrow down millions of SNPs to a smaller number with a high potential to induce interferon regulation of nearby genes. These SNPs can finally be reviewed manually, laying the groundwork for a more focused and efficient exploration of regulatory SNPs in an experimental setting.
Authors
- Markus Hoffmann (ORCID: https://orcid.org/0000-0002-1920-288X)
- Lothar Hennighausen (ORCID: https://orcid.org/0000-0001-8319-9841)
- Tiago A. Vaz (ORCID: https://orcid.org/0000-0002-6671-4132)
- Shreeti Chhatrala
Institutions
- National Institutes of Health (US)
- Georgetown University (US)
- Georgetown University Medical Center (US)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s12864-025-11374-7
- Citations
- 2
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Institutes of Health