Ovarian function and response to gonadotropins after prolonged perfusion of whole ewe ovaries in a bioreactor
This study is the first to report the successful harvesting of MII oocytes following extended ex vivo perfusion of intact ewe ovaries, highlighting the potential of the perfusion model to support advanced follicular development. Further investigations are warranted to elucidate underlying mechanisms and refine protocol efficiency.
Authors
- Constantina Mateoiu (ORCID: https://orcid.org/0000-0003-2554-949X)
- Mats Hellström (ORCID: https://orcid.org/0000-0002-7088-9533)
- Edina Sehiç (ORCID: https://orcid.org/0000-0003-3457-1111)
- Panagiotis Tsiartas (ORCID: https://orcid.org/0000-0002-1785-8535)
- Lucía de Miguel–Gómez (ORCID: https://orcid.org/0000-0001-6556-9108)
- Pasquale Patrizio (ORCID: https://orcid.org/0000-0003-4796-7078)
- Randa Akouri (ORCID: https://orcid.org/0000-0001-5524-0165)
- Prajakta Hatekar
Institutions
- University of Miami (US)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- Stockholm IVF (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Assisted Reproduction and Genetics
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1007/s10815-025-03432-6
- Citations
- 1
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Göteborgs Universitet