Blood gene expression of Toll-like receptors in SLE patients with lupus nephritis or neuropsychiatric systemic lupus erythematosus
Our study revealed differences in TLR expression between a lupus cohort and healthy controls. Additionally, our analysis provides insight into specific TLR expression in cases with severe organ manifestations, such as LN and NPSLE. The multiple mutual relationships of TLRs demonstrate the activation of innate immunity in SLE and suggest promising targets for future therapies or diagnostics.
Authors
- Eva Kriegová (ORCID: https://orcid.org/0000-0002-8969-4197)
- Andrea Smržová (ORCID: https://orcid.org/0000-0003-3505-4757)
- František Mrázek (ORCID: https://orcid.org/0000-0002-9981-7517)
- Jirina Manakova (ORCID: https://orcid.org/0000-0001-6931-5666)
- Anna Petráčková (ORCID: https://orcid.org/0000-0001-5210-4504)
- Miloš Kudělka (ORCID: https://orcid.org/0000-0002-7219-1008)
- Martina Skácelová (ORCID: https://orcid.org/0000-0001-8193-5278)
- Veronika Šmotková Kraiczová (ORCID: https://orcid.org/0000-0002-5264-0873)
- Kateřina Langová (ORCID: https://orcid.org/0000-0003-2387-0183)
- Pavel Hořák (ORCID: https://orcid.org/0000-0002-2394-064X)
- Marketa Dudkova (ORCID: https://orcid.org/0000-0001-9060-5182)
- Jakub Videman (ORCID: https://orcid.org/0000-0003-3284-477X)
- Martin Radvansky (ORCID: https://orcid.org/0000-0003-0901-7397)
Institutions
- VSB - Technical University of Ostrava (CZ)
- University Hospital Olomouc (CZ)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s13075-025-03512-z
- Citations
- 2
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 1.59