Targeting mesothelin-CD24 axis repolarizes tumor-associated macrophages to potentiate PD-1 blockade therapy in high-grade serous ovarian cancer
This study elucidates the critical role of MSLN in immune evasion in HGSOC and its underlying mechanisms. Targeting MSLN in combination with ICB is a promising strategy to enhance the efficacy of immunotherapy and improve patient outcomes in HGSOC.
Authors
- Xueling Wang (ORCID: https://orcid.org/0000-0002-5969-5172)
- Yiying Wang (ORCID: https://orcid.org/0000-0002-9661-6111)
- Moran Yang (ORCID: https://orcid.org/0000-0002-0601-9090)
- Haiou Liu (ORCID: https://orcid.org/0000-0003-0200-8981)
- Kankan Cao (ORCID: https://orcid.org/0000-0001-9242-1440)
- Y C Zhong (ORCID: https://orcid.org/0009-0006-6559-0736)
- Xuyao Xu
- Guodong Zhang (ORCID: https://orcid.org/0009-0002-3481-8145)
- Chenyang Wang (ORCID: https://orcid.org/0000-0003-1865-7572)
- Jiaqi Lu (ORCID: https://orcid.org/0000-0002-5646-0298)
Institutions
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-011230
- Citations
- 15
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 15.68
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Shanghai Clinical Research Center
- Science and Technology Innovation Plan Of Shanghai Science and Technology Commission