ROLE OF IL-1β, IL-6, TNF-α, INF-γ, IL-4, IL-10 and TGF-β CYTOKINES IN THE DIAGNOSIS OF ROTAVIRUS INFECTION IN CHILDREN

The purpose of the study. To evaluate the diagnostic significance of cytokines IL-1β, IL-6, TNF-α, INF-γ, IL- 4, IL-10 and TGF-β in children with rotavirus infection. Materials and methods. The study analyzed 46 cases of hospitalized rotavirus infection in children aged 6 to 59 months (average age 23 months [16; 34]) in the early period of the disease. Serum cytokine levels (IL-1β, IL-6, TNF-α, INF-γ, IL-4, IL-10 and TGF-β1) were measured in all children using flow fluorimeter. The results were processed using software IBM SPSS Statistics 26. Results. In the group of children with rotavirus infection, a statistically significant increase in the level of the studied cytokines IL-4, IL-1β, IL-6, IFN-γ, and TGF-β1 was detected compared to the control group. According to the results, the cytokines IL-1β and IL-6 turned out to be the most informative for the diagnosis of rotavirus infection. Conclusions. It has been established that the determination of serum levels of IL-1β, IL-6 and IFN-γ can be used as an additional diagnostic criterion for rotavirus gastroenteritis.