Disruption of GPSM1/CSF1 signaling reprograms tumor-associated macrophages to overcome anti-PD-1 resistance in colorectal cancer
Our findings highlight the pivotal role of GPSM1-driven M2 macrophage infiltration in mediating anti-PD-1 resistance in CRC. Targeting GPSM1 offers a novel therapeutic strategy to enhance ICB efficacy, potentially broadening the patient population that may benefit from these therapies.
Authors
- Yifan Yao (ORCID: https://orcid.org/0000-0003-3687-2102)
- Huiqing Jia (ORCID: https://orcid.org/0009-0004-5658-8277)
- Xiangyan Zhang (ORCID: https://orcid.org/0009-0005-7905-6983)
- Han Zhao (ORCID: https://orcid.org/0000-0002-8243-7411)
- Yang Chen (ORCID: https://orcid.org/0009-0004-0674-4147)
- Na Li (ORCID: https://orcid.org/0009-0006-9447-6908)
- Yujing Xiao (ORCID: https://orcid.org/0000-0002-5523-5507)
- Xiaoming Xing
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010826
- Citations
- 7
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.58