Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients
Our study highlights the critical role of hypoxia in shaping T cell distribution and its correlation with clinical outcomes in melanoma. We revealed a preferential accumulation of T cells in oxygenated areas. Moreover, hypoxic T cells develop a distinct hypoxic gene signature prevalent in resting, non-activated T cells and T<sub>STR</sub> that was also associated with poorer outcomes, particularly pronounced among non-responders to ICIs.
Authors
- Elena V. Kostenko (ORCID: https://orcid.org/0000-0003-0629-9659)
- Katarzyna A. Rejniak (ORCID: https://orcid.org/0000-0003-2093-2422)
- José A. Guevara-Patiño (ORCID: https://orcid.org/0000-0002-6258-7228)
- Awino Maureiq E. Ojwang’ (ORCID: https://orcid.org/0009-0000-3275-1974)
- Ahmad A. Tarhini (ORCID: https://orcid.org/0000-0002-3193-9702)
- Mate Z Nagy (ORCID: https://orcid.org/0000-0001-5845-0926)
- Joshua Saul Davis (ORCID: https://orcid.org/0000-0001-9864-5699)
- Timothy I. Shaw (ORCID: https://orcid.org/0000-0002-9316-1924)
- Lourdes Plaza-Rojas (ORCID: https://orcid.org/0000-0003-1795-185X)
- Alyssa Obermayer (ORCID: https://orcid.org/0000-0002-7333-973X)
- Justin C. Boucher (ORCID: https://orcid.org/0009-0008-8936-0470)
- Dongliang Du (ORCID: https://orcid.org/0000-0002-0881-7563)
- Zhihua Chen (ORCID: https://orcid.org/0000-0003-2457-4802)
- Anna L Austin
Institutions
- Moffitt Cancer Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010153
- Citations
- 5
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- Moffitt Cancer Center
- National Institutes of Health
- National Cancer Institute