Immunological biomarkers of response and resistance to treatment with cabozantinib and nivolumab in recurrent endometrial cancer
Overall, this study highlights potential resistance and response mechanisms to nivolumab+cabozantinib and suggests prioritizing combination treatment in patients with activated T-cell immunogenicity profiles while exploring future combinatorial therapies targeting myeloid populations to overcome resistance.
Authors
- Vladimir Roudko (ORCID: https://orcid.org/0000-0002-3835-6737)
- Diane M. Del Valle (ORCID: https://orcid.org/0000-0001-6983-5362)
- Ryan C. Thompson (ORCID: https://orcid.org/0000-0002-0450-8181)
- Kevin Tuballes (ORCID: https://orcid.org/0000-0002-5899-7080)
- Ignacio I. Wistuba (ORCID: https://orcid.org/0000-0003-3365-6340)
- Lisa Wang (ORCID: https://orcid.org/0000-0001-9726-0383)
- Gheath Alatrash (ORCID: https://orcid.org/0000-0002-7648-4377)
- Stéphanie Lheureux (ORCID: https://orcid.org/0000-0003-4405-5890)
- Edgar Gonzalez‐Kozlova (ORCID: https://orcid.org/0000-0002-6948-0626)
- Manishkumar Patel (ORCID: https://orcid.org/0000-0002-7949-5610)
- Cara Haymaker (ORCID: https://orcid.org/0000-0002-1317-9287)
- Seunghee Kim‐Schulze (ORCID: https://orcid.org/0000-0003-0192-4400)
- Geoff Kelly (ORCID: https://orcid.org/0000-0002-1149-0717)
- Mayte Suárez‐Fariñas (ORCID: https://orcid.org/0000-0001-8712-3553)
- Ganiraju C. Manyam
- Sacha Gnjatic (ORCID: https://orcid.org/0000-0001-5643-9520)
- HOWARD Z. STREICHER (ORCID: https://orcid.org/0000-0003-3683-9804)
- Swati Atale
- Jianjun Zhang (ORCID: https://orcid.org/0000-0001-7872-3477)
- Hui Xie (ORCID: https://orcid.org/0000-0003-4299-2776)
- Emir Radkevich
- Benito CzinCzin
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Princess Margaret Cancer Centre (CA)
- Tisch Hospital (US)
- National Cancer Institute (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010541
- Citations
- 7
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 14.40
Funders
- Conquer Cancer Foundation
- National Cancer Institute
- National Center for Advancing Translational Sciences
- Moonshot Research and Development Program
- Cancer Moonshot