A framework to standardize gait study protocols in Parkinson's disease
BackgroundResearch over the past twenty years has shown that gait outcomes have a high sensitivity for diagnosing Parkinson's disease (PD), for detecting the effects of interventions, and for monitoring disease progression, even in early disease. However, the lack of standardization in protocols and reported gait measures is impeding data aggregation across study sites and contributes to heterogeneity in the results, thus limiting the adoption of gait outcomes in clinical trials.ObjectiveTo provide recommendations for a minimum set of gait measures to be adopted in projects evaluating people with PD to enhance standardization across the field.MethodsThe Gait Advisors Leading Outcomes for Parkinson's (GALOP) committee is an advisory committee for the MJFF. Based on a five-step approach, GALOP generated recommendations for standardizing protocols that assess quantitative gait measures, following expert consensus on best practices.ResultsBuilt on the literature and consensus amongst experts, we recommend a minimum set of meta-data to accompany gait protocols and a minimum gait assessment protocol to be performed at a comfortable speed. Suggestions on challenging testing are provided.ConclusionsTo support and empower the scientific community, we have generated recommendations to collect and share gait data gathered from people with PD using an open data repository. Standardizing gait protocols and outcomes in PD has the potential of accelerating research and clinical trials, harmonizing protocols across study sites, fostering collaborations, and in the long run, improving patient care and quality of life.
Authors
- Jeffrey M. Hausdorff (ORCID: https://orcid.org/0000-0002-1608-0776)
- Catherine Kopil (ORCID: https://orcid.org/0000-0001-8678-7550)
- Martina Mancini (ORCID: https://orcid.org/0000-0002-4532-3984)
- Katharina Klapper (ORCID: https://orcid.org/0009-0004-9157-8381)
- Elisa Pelosin (ORCID: https://orcid.org/0000-0002-9880-2241)
- Alice Nieuwboer (ORCID: https://orcid.org/0000-0003-1193-6229)
- David Trevor Dexter (ORCID: https://orcid.org/0000-0002-7974-9588)
- Rosie Fuest
- Larry Gifford (ORCID: https://orcid.org/0000-0002-3594-2757)
- Vonda H. Miller
- Alfonso A. Fasano (ORCID: https://orcid.org/0000-0001-5346-0180)
- Richard Camicioli (ORCID: https://orcid.org/0000-0003-2977-8660)
- Paolo Bonato (ORCID: https://orcid.org/0000-0002-1818-1714)
- Jochen Klucken (ORCID: https://orcid.org/0000-0001-6645-9437)
- Martijn L.T.M. Müller (ORCID: https://orcid.org/0000-0002-1133-7202)
- Anat Mirelman (ORCID: https://orcid.org/0000-0002-1520-2292)
- Diane T. Stephenson (ORCID: https://orcid.org/0000-0002-4262-436X)
- L. Kirsch (ORCID: https://orcid.org/0009-0009-5874-1593)
- Terry D. Ellis (ORCID: https://orcid.org/0000-0001-7067-4527)
- Angelica Asis
Institutions
- Boston University (US)
- Rush University Medical Center (US)
- Harvard University (US)
- University of Alberta (CA)
- Tel Aviv University (IL)
- Oregon Health & Science University (US)
- University of Toronto (CA)
- University of Luxembourg (LU)
- Toronto Western Hospital (CA)
- Critical Path Institute (US)
- Michael J. Fox Foundation (US)
- Parkinson's UK (GB)
- Ospedale Policlinico San Martino (IT)
- Ontario Brain Institute (CA)
- Krembil Brain Institute
- KU Leuven (BE)
Publication Details
- Journal
- Journal of Parkinson s Disease
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1177/1877718x241305626
- Citations
- 11
- Primary Topic
- Balance, Gait, and Falls Prevention
- Type
- article
- Field-Weighted Citation Impact
- 52.36
Funders
- Michael J. Fox Foundation for Parkinson's Research