Pharmacokinetic effect of disease severity and use of extracorporeal membrane oxygenation in critically ill Asian patients receiving vancomycin
The study demonstrates that ECMO and infection severity are major factors influencing vancomycin clearance in critically unwell pediatric patients. The significant decrease in clearance linked to ECMO and reduced infection severity underscores the necessity for meticulous therapeutic drug monitoring and tailored dosing strategies to enhance vancomycin treatment in this at-risk population. The findings highlight the significant interindividual diversity in vancomycin pharmacokinetics in critically unwell pediatric patients.
Authors
- Charul Avachat (ORCID: https://orcid.org/0000-0002-5052-7981)
- Angela K. Birnbaum (ORCID: https://orcid.org/0000-0002-3969-4906)
- Daniel P. Healy (ORCID: https://orcid.org/0009-0008-4466-8017)
- Catherine M.T. Sherwin (ORCID: https://orcid.org/0000-0002-0844-3207)
- Alex C. Lin
- Pei‐Yu Hung (ORCID: https://orcid.org/0000-0002-8037-3557)
Institutions
- University of Minnesota (US)
- Kaohsiung Medical University (TW)
- The University of Western Australia (AU)
- Wright State University (US)
- Kaohsiung Veterans General Hospital (TW)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fphar.2025.1506793
- Citations
- 2
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 2.79