The role of HDAC2 inhibition in cardioprotection against doxorubicin-induced myocardial injury
Suppressing HDAC2 protected against DOX-induced cardiomyocyte apoptosis by activating the PI3K/AKT signaling pathway. Therefore, HDAC2 is a promising therapeutic target for mitigating DOX-induced myocardial injury.
Authors
- Jinsha Liu (ORCID: https://orcid.org/0000-0002-3636-8080)
- Xue Wang (ORCID: https://orcid.org/0000-0002-5984-0878)
- Zuowen Liang
- Wenwen Fu
- Fanbo Meng
Institutions
- Union Hospital (HK)
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fcvm.2025.1557119
- Citations
- 1
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Department of Science and Technology of Jilin Province