FSTL1 accelerates nucleus pulposus-derived mesenchymal stem cell apoptosis in intervertebral disc degeneration by activating TGF-β-mediated Smad2/3 phosphorylation
This study provides novel insights into the mechanistic role of FSTL1 in acid-induced apoptosis of NP-MSCs and its contribution to the progression of IVDD. These findings offer valuable perspectives for developing targeted therapeutic strategies to mitigate IVDD progression.
Authors
- Chong-Yu Jia (ORCID: https://orcid.org/0000-0003-4922-9255)
- Liang Kang (ORCID: https://orcid.org/0000-0001-6015-2071)
- Cailiang Shen (ORCID: https://orcid.org/0000-0002-9835-6384)
- Lu-Ping Zhou (ORCID: https://orcid.org/0000-0001-5282-769X)
- Jing-Yu Ding
- Renjie Zhang (ORCID: https://orcid.org/0000-0001-7055-5720)
- Xiaoying Liu (ORCID: https://orcid.org/0000-0003-3450-5683)
- Xu Yan
- Huaqing Zhang (ORCID: https://orcid.org/0000-0002-1519-9919)
- Yanxin Wang (ORCID: https://orcid.org/0000-0003-1761-4706)
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-26
- DOI
- https://doi.org/10.1186/s12967-025-06231-w
- Citations
- 6
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 8.83