Autism spectrum disorder related phenotypes in a mouse model lacking the neuronal actin binding protein profilin 2
Our data directly link altered pre-synaptic actin dynamics to autism spectrum disorder in the mouse model and support the hypothesis that synaptic dysfunctions that asymmetrically increase the excitatory drive in neuronal circuits can lead to autistic-like phenotypes. Our findings inspire to consider novel potential pathways for therapeutic approaches in ASD.
Authors
- Marina Di Domenico (ORCID: https://orcid.org/0000-0002-6201-4200)
- Laura Maggi (ORCID: https://orcid.org/0000-0003-2862-9591)
- Alessia Di Nardo (ORCID: https://orcid.org/0000-0002-0025-7290)
- Pietro Pilo Boyl (ORCID: https://orcid.org/0000-0002-7535-4802)
- Valentin Stein (ORCID: https://orcid.org/0000-0003-1222-4928)
- Walter Witke
Institutions
- Biogen (United States) (US)
- University of Bonn (DE)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fncel.2025.1540989
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00