Burn inhalation injury and intubation with dexamethasone-eluting endotracheal tubes modulate local microbiome and alter airway inflammation
Thermal inhalation injury and ETT placement significantly impact airway inflammation, structural integrity, and microbiome composition. Dexamethasone-eluting ETTs, intended to reduce inflammation, increased biofilm formation and elevated cytokine levels, suggesting complex interactions between the drug coating and the host immune response. The airway microbiome shifted significantly with specific taxa thriving in the inflamed environment.
Authors
- Gabriela Gonzales (ORCID: https://orcid.org/0000-0003-3958-0914)
- Teja Guda (ORCID: https://orcid.org/0000-0002-3218-2916)
- Ronit Malka (ORCID: https://orcid.org/0000-0002-9864-2698)
- Gregory R. Dion (ORCID: https://orcid.org/0000-0003-4389-3104)
- Rena Bizios (ORCID: https://orcid.org/0000-0003-2939-4632)
Institutions
- Brooke Army Medical Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- The University of Texas at San Antonio (US)
- University of Cincinnati (US)
- Joint Base San Antonio (US)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fbioe.2025.1524013
- Citations
- 1
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.52