Exploring the therapeutic potential of “Zhi-Zhen” formula for oxaliplatin resistance in colorectal cancer: an integrated study combining UPLC-QTOF-MS/MS, bioinformatics, network pharmacology, and experimental validation
ZZF has potential clinical value in the treatment of chemoresistance in CRC by inhibiting the transcription and nuclear localization of <i>β</i>-catenin, thereby increasing the expression of CASP7 and enhancing the apoptotic response in chemoresistant CRC cells.
Authors
- Xiuming Li (ORCID: https://orcid.org/0000-0002-9616-723X)
- Yongjing Li
- Ke Chen (ORCID: https://orcid.org/0000-0002-8022-5837)
- Songpo Wang
- Huijie Han (ORCID: https://orcid.org/0000-0001-9701-5839)
- Qin Li (ORCID: https://orcid.org/0000-0001-5015-0750)
- Qiaoli Liu
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai First People's Hospital (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fmed.2025.1516307
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00