Prolactin drives cortical neuron maturation and dendritic development during murine embryonic stem cell differentiation
These findings highlight PRL's pivotal role as a regulator of early corticogenesis by modulating neuronal survival, dendritic development, and astrocyte maturation. PRL thus emerges as a potential key factor in neurodevelopment, underscoring its importance in the hormonal regulation of neural differentiation and maturation. These insights may have broader implications for understanding the molecular and cellular mechanisms underlying normal and pathological neurodevelopment.
Authors
- Alejandro López‐Saavedra (ORCID: https://orcid.org/0000-0002-3838-4738)
- Daniela Ávila‐González (ORCID: https://orcid.org/0000-0003-4817-6630)
- Alejandro Martínez-Juárez (ORCID: https://orcid.org/0000-0003-1204-3860)
- Georgina Hernández‐Montes
- Eliezer Flores-Garza (ORCID: https://orcid.org/0000-0003-3301-9624)
- Emmanuel Diaz (ORCID: https://orcid.org/0000-0002-6596-050X)
- Wendy Portillo (ORCID: https://orcid.org/0000-0002-5651-4815)
- Omar Martínez-Alarcón
- Anayansí Molina‐Hernández
- Alejandra Castilla
- Néstor Fabián Díaz
- Daniela Colin-Lagos
- Ximena Ramirez-Meza
Institutions
- Secretaría de Salud de Jalisco (MX)
- Instituto Nacional de Perinatología (MX)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Instituto Nacional de Cancerología (MX)
- Imperial College London (GB)
- Universidad Nacional Autónoma de México (MX)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fcell.2025.1551090
- Citations
- 2
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.63