Multi-centered clinical validation demonstrating superior precision in lupus diagnosis: T cell autoantibodies and TC4d outperform conventional lupus erythematosus biomarkers
The novel SLE biomarkers TC4d, TIgG and TIgM consistently outperform conventional markers across multiple cohorts. Their integration enhances diagnostic sensitivity, especially in SLE-specific autoantibody negative patients with normal complement levels. When coupled with conventional biomarkers, these novel tests may enable earlier and more accurate SLE detection, leading to more timely diagnosis and treatment.
Authors
- Andrew L. Concoff (ORCID: https://orcid.org/0000-0001-8325-760X)
- Seyed Alireza Taghavi (ORCID: https://orcid.org/0000-0001-5360-6776)
- Brittany D. Partain (ORCID: https://orcid.org/0000-0003-0190-0062)
- Vasileios C. Kyttaris (ORCID: https://orcid.org/0000-0001-7652-3826)
- C C Liu (ORCID: https://orcid.org/0009-0004-3395-0333)
- Tyler O’Malley (ORCID: https://orcid.org/0000-0002-4439-1395)
- Daniel J. Wallace (ORCID: https://orcid.org/0000-0002-2502-1372)
- Stanley Park
- Arezou Khosroshahi (ORCID: https://orcid.org/0000-0001-8365-8497)
- Susan Manzi
- Joseph M. Ahearn
- Nicole Wilson
- Touba Warsi
- Christine Schleif
Institutions
- Cedars-Sinai Medical Center (US)
- Allegheny Health Network (US)
- Beth Israel Deaconess Medical Center (US)
- Emory University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1518208
- Citations
- 2
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 3.34