Investigation of the role of miRNA variants in neurodegenerative brain diseases
Functional investigation of miRNAs/variants described in this study could propose novel miRNA-mediated molecular cascades in FTD and AD pathogenicity. Furthermore, we believe that the genetic evidence presented here suggests a role for <i>MIR885</i> in molecular mechanisms involved in AD and warrants genetic follow-up in larger cohorts to explore this hypothesis.
Authors
- Alexandros Frydas
- Christine Van Broeckhoven (ORCID: https://orcid.org/0000-0003-0183-7665)
- Rita Cacace (ORCID: https://orcid.org/0000-0002-0180-3687)
- Julie van der Zee (ORCID: https://orcid.org/0000-0003-4381-8040)
- Eline Wauters (ORCID: https://orcid.org/0000-0002-8837-1900)
Institutions
- University of Antwerp (BE)
- VIB-UAntwerp Center for Molecular Neurology (BE)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fgene.2025.1506169
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Fonds Wetenschappelijk Onderzoek