Synergistic antifungal effects and mechanisms of amantadine hydrochloride combined with azole antifungal drugs on drug-resistant Candida albicans
This study provides strong evidence that combinations of non-antifungal drugs and antifungal drugs can effectively overcome drug-resistant <i>C. albicans</i> infection. Both AMH and FLC are FDA-approved drugs, eliminating concerns about safety. Our findings provide a foundation for further clinical antifungal research.
Authors
- Shicun Zheng (ORCID: https://orcid.org/0000-0002-2345-9039)
- Yuanyuan Zhi
- Min Cui (ORCID: https://orcid.org/0000-0001-9691-033X)
- Chen Xu (ORCID: https://orcid.org/0000-0001-5146-5260)
- Ximeng Duan
- Xiuyun Li (ORCID: https://orcid.org/0000-0002-0764-7769)
Institutions
- Qingdao University (CN)
- Taizhou Central Hospital (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fcimb.2025.1455123
- Citations
- 3
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 4.19