Genistein Exerts Anti-proliferative Effects by Regulating Apoptosis and Autophagy-Related Genes and MicroRNAs in Human Urinary Bladder Neoplasm EJ138 Cells: An Experimental and Bioinformatic Study
The results of this study suggest that genistein suppresses the proliferation and growth of human BC cells by modulating genes and microRNAs involved in apoptosis and autophagy. Therefore, genistein may serve as a novel therapeutic agent for BC treatment.
Authors
- Ali Nosrat (ORCID: https://orcid.org/0000-0003-4768-9717)
- Mohammad Amin Vatankhah (ORCID: https://orcid.org/0000-0002-8855-6614)
- Farid Pakizeh
- Sina Seifimansour (ORCID: https://orcid.org/0009-0000-4410-1741)
- Pouria Sobhi (ORCID: https://orcid.org/0000-0003-0800-536X)
- Alireza Ziyabakhsh (ORCID: https://orcid.org/0000-0003-4724-0901)
- Mohammad Vakili-Ojarood (ORCID: https://orcid.org/0000-0002-4396-5828)
Institutions
- Tabriz University of Medical Sciences (IR)
- Ardabil University of Medical Sciences (IR)
- Imam Reza Hospital (IR)
Publication Details
- Journal
- Iranian journal of pharmaceutical research
- Published
- 2025-02-22
- DOI
- https://doi.org/10.5812/ijpr-157853
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61