Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease
These cell-type specific vulnerabilities may underlie degenerative endophenotypes suggesting precision medicine targeting of individual populations of neurons for rational therapeutic development.
Authors
- Adriana Heguy (ORCID: https://orcid.org/0000-0002-2836-6683)
- Gabriela Chiosis (ORCID: https://orcid.org/0000-0003-0486-6920)
- Stephen D. Ginsberg (ORCID: https://orcid.org/0000-0002-1797-4288)
- Melissa J. Alldred (ORCID: https://orcid.org/0000-0002-5701-0694)
- Grace E. Stutzmann (ORCID: https://orcid.org/0000-0003-2841-8532)
- Harshitha Pidikiti (ORCID: https://orcid.org/0009-0001-0862-0883)
- Sang H. Lee (ORCID: https://orcid.org/0000-0001-9760-393X)
- Kyrillos W. Ibrahim
- Elliott J. Mufson
Institutions
- Nathan Kline Institute for Psychiatric Research (US)
- Barrow Neurological Institute (US)
- Memorial Sloan Kettering Cancer Center (US)
- Rosalind Franklin University of Medicine and Science (US)
- Kettering University (US)
- New York University (US)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fnmol.2025.1546375
- Citations
- 2
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 3.76