Low-level neurostimulation of the renal nerves as a potential therapeutic strategy for hypertension treatment
Low-level RNS effectively lowers BP in the SHR model of hypertension and may offer a promising therapeutic alternative for hypertension treatment. Physiologically, the observed clinically relevant reductions in BP were primarily due to reductions in vascular resistance. Adjusting stimulus levels can achieve desired hypotensive responses without compromising ipsilateral renal blood supply, typically affected by direct renal sympathetic fiber stimulation.
Authors
- Arun Sridhar (ORCID: https://orcid.org/0000-0002-8682-6545)
- Ibrahim M. Salman (ORCID: https://orcid.org/0000-0003-4825-5320)
- Yee‐Hsee Hsieh (ORCID: https://orcid.org/0000-0002-7108-0349)
- Sarah F. Hassan
- Omar Z. Ameer (ORCID: https://orcid.org/0000-0002-9211-9791)
- Stephen J. Lewis (ORCID: https://orcid.org/0000-0001-7050-0666)
Institutions
- Alfaisal University (SA)
- Case Western Reserve University (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-26
- DOI
- https://doi.org/10.3389/fphar.2025.1529844
- Citations
- 2
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.78